探討健康成年人B-維生素 (葉酸、維生素B-12及B-6) 的營養狀況與高同半胱胺酸血症的相關性

Abstract

To provide more information on B-vitamins (folate, vitamin B-12 and vitamin B-6) in relation to fasting and post methionine loading (PML) homocysteine (Hcy) concentrations, we examined folate, vitamin B-12, B-6 and PML homocysteine in normo-homocysteinemia (N-Hcy, <12 mmol/L) and hyperhomocysteinemia (H-Hcy, s 12mmol/L) adults. One hundred and ninety-nine 31-50 years old healthy men (n = 100) and women (n = 99) were recruited from the community and assigned to either the N-Hcy (n = 145) or H-Hcy (n = 54) group. Fasting and PML Hcy, hematological parameters were measured. Fasting and PML Hcy of women in N-Hcy were significant lower than men. Subjects in the N-Hcy group had significantly higher serum folate and vitamin B-12 and lower PML homocysteine concentrations than H-Hcy subjects did. There was no significant difference in vitamin B-6 values between groups. However, serum folate (β = -0.153, p = 0.002) was strongly inversely associated with fasting plasma homocysteine; vitamin B-12 was inversely correlated with PML homocysteine (β = -0.002, p = 0.027). High serum folate concentration (OR = 0.784, p < 0.001) significantly decreased the risk of fasting hyperhomoycsteinemia. High serum folate concentration might be a protective factor of hyperhomocysteinemia in the healthy adult population.