B-AB08-01 SUDDEN CARDIAC DEATH IN THE YOUNG IN THE UNITED STATES FROM 2015 TO 2018

Abstract

Sudden cardiac death in the young (SCDY) is incompletely described. The NIH/CDC Sudden Death in the Young (SDY) Case Registry collects standardized, population-based data. To explore mortality rates and characteristics of SCDY. Using SDY Case Registry data, we analyzed sudden, unexpected deaths from 2015-2018 categorized as Explained Cardiac (EC) (definitive cardiac cause identified after investigation) among residents 0-17 years old in 9 states/jurisdictions. We described demographics, diagnoses, and activity level, and calculated population-based mortality rates. Among 2,153 Registry cases, 95 were categorized as EC (29 infants [<1 year], 66 children). Most cases were autopsied (98%). The EC mortality rate was 0.37/100,000 child population. (Table) EC was more frequent among infants and children 1 or 14-17 years than children 2-13 years. EC was more common among males and black children. The most common causes of EC were myocarditis, congenital heart disease (CHD), and hypertrophic cardiomyopathy (HCM). In infants, CHD and myocarditis predominated. Among 14-17 year-old children, the most common causes of EC were HCM and coronary anomalies. More EC cases occurred at rest. Most exertional deaths occurred in 14-17 year-old children and were due to coronary artery anomalies, myocarditis, and various types of cardiomyopathy. Of the deaths during rest, myocarditis the was most common cause. The SDY Case Registry provides important information on SCDY in the US population. Exploring age differences in EC causes may inform prevention efforts.