B-135 Research Trends and Hotspots of Glial Fibrillary Acidic Protein in Body Fluid for Alzheimer’s Disease: A Bibliometric Analysis

Abstract

Abstract Background As the most common form of dementia, Alzheimer’s disease (AD) is prevalent worldwide. An increasing number of studies have focused on glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, for the development, diagnosis and prognosis of AD. Therefore, this study aimed to analyze trends and hotspots of GFAP in body fluid for AD by using a bibliometric method, which is missing in current publications. Methods We systematically searched the Web of Science Core Collection for published papers on GFAP in body fluid and AD. All articles and reviews from inception to December 31, 2022, were included in this study. Full records and cited references of all publications were derived, imported into Microsoft Excel, and analyzed by BIBLIOMETRC Online analysis platform and VOSviewer software. Results A total of 2269 publications including 2166 articles were ultimately included based on the inclusion criteria. The data showed that the number of published papers on GFAP in body fluid and AD is annually increasing, which was published in 81 countries/regions and 527 academic journals. Separately, the top 3 prolific countries/regions and institutions were USA, China and England, Univ Gothenburg (Sweden), Univ Fed Rio Grande do Sul (Brasilia) and UCL Queen Square Institute of Neurology (England). Journal of Alzheimer’s Disease, Brain Research, and Neuroscience contributed the most publications; Zetterberg, Henrik from Univ Gothenburg, Blennow, Kaj from Univ Gothenburg and Verkhratsky, Alexei from the University of Manchester were the top 3 prolific and cited authors. The most published and linked meaningful keywords included oxidative stress, inflammation, microglia, hippocampus and amyloid, which also annually increased in recent publications. Conclusion Based on a bibliometric analysis, the number of publications on GFAP in body fluid and AD are rapidly increasing, especially in the past several years. Oxidative stress and inflammation are research hotspots, and the diagnostic performance of GFAP in body fluid need to be further summarized and verified.