Abstract
AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate. Selectivity for ADP over ATP, AMP and PPi results from appropriate positioning of the receptor motifs, since an isomeric sensor cannot discriminate between ADP and ATP.
Highlights
AzuFluors 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate
Selectivity for adenosine diphosphate (ADP) over Adenosine triphosphate (ATP), Adenosine monophosphate (AMP) and pyrophosphate anion (PPi) results from appropriate positioning of the receptor motifs, since an isomeric sensor cannot discriminate between ADP and ATP
Other Zn-DPA-based sensors exhibit their largest fluorescence response in the presence of a particular nucleotide, often ATP;[6] for such sensors, discrimination between nucleotides can sometimes be effected on the basis of spectroscopic features such as change in ratiometric fluorescence intensities.[7]
Summary
AzuFluors 435-DPA-Zn, an azulene fluorophore bearing two zinc(II)dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate. Selectivity for ADP over ATP, AMP and PPi results from appropriate positioning of the receptor motifs, since an isomeric sensor cannot discriminate between ADP and ATP.
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