Abstract
Azole-Resistant<i>Aspergillus fumigatus</i>, Iran
Highlights
We investigated the prevalence of azole resistance in clinical A. fumigatus isolates stored for 6 years (2003– 2009) at Tehran University Mycology Reference Centre and Islamic Azad University, Ardabil Branch, Iran
We investigated 124 clinical A. fumigatus isolates obtained from patients with Aspergillus diseases
We performed microsatellite genotyping of all A. fumigatus isolates for which the MIC of itraconazole was >16 mg/L [8] by using a short tandem repeat A. fumigatus assay, and we compared the results with those reported for the Netherlands (20 isolates) and other European countries (24 isolates)
Summary
Chirico J, Stenkula S, Eriksson B, Gjötterberg M, Ingemansson SO, PehrsonPalmqvist G, et al Reindeer warble fly larva as a cause of 3 cases of human myiasis [in Swedish]. Azole resistance is thought to be selected for as a result of patient therapy or exposure to azole compounds in the environment; resistance in clinical A. fumigatus isolates has been increasingly reported in several European countries, Asia, and the United States [3,4,5,6,7]. Because routine in vitro susceptibility testing of clinical Aspergillus isolates is not common in many centers worldwide, the prevalence of azole resistance might be underestimated.
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