Azithromycin to Prevent Recurrent Wheeze Following Severe RSV bronchiolitis: The APW-RSV II Clinical Trial

Avraham Beigelman,Yanjiao Zhou,Mythili Srinivasan,Elizabeth Ahrens,Dana Burgdorf,Mario Castro,Jinli Wang,Kelly True,Watcharoot Kanchongkittiphon,Gregory A Storch ,Andrea M Coverstone ,S Bram ,Timothy J Casper ,Cadence Kuklinski ,Matthew D Haslam ,Huiqing Yin‐Declue ,Charles W Goss ,Kenneth B Schechtman ,Jonathan S Boomer ,Meghan A Wallace ,Carey-Ann D Burnham ,Leonard B Bacharier

doi:10.1016/j.jaci.2021.12.508

Abstract

Early life severe Respiratory Syncytial Virus (RSV) bronchiolitis is a risk factor for childhood asthma. As azithromycin may attenuate airway inflammation during RSV bronchiolitis, we evaluated if it would reduce the occurrence of recurrent wheeze (RW).

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