Abstract
One of the many challenges for clinical trials during a pandemic such as COVID-19 is the need to provide reliable and clear answers rapidly. High-quality, adequately powered, simple randomised clinical trials have been crucial in advancing knowledge of potential treatments for COVID-19.1 Principles underpinning such trials include the use of the uncertainty principle to determine eligibility, which allows for rapid enrolment of participants and streamlined data collection, making these studies easy to implement in routine practice.
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