Abstract
Methods of large-scale controllable production of uniform monodispersed spherical nanoparticles have been one of the research directions of scientists in recent years. In this paper, we report an azeotropic distillation-induced evaporation self-assembly method as a universal method, and monodispersed hydrophobic ordered mesoporous silica nanospheres (MHSs) were successfully synthesized by this method, using triethoxymethylsilane (MTES) as the silica precursor and hexadecyl trimethyl ammonium bromide (CTAB) as the template. SEM and TEM images showed good monodispersity, sphericity, and uniform diameter. Meanwhile, SAXS and N2 adsorption–desorption measurements demonstrated a highly ordered lamellar mesostructure with a large pore volume. The model drug, curcumin was successfully encapsulated in MHSs for drug delivery testing, and their adsorption capacity was 3.45 mg g−1, which greatly improved the stability of curcumin. The release time when net release rate of curcumin reached 50% was extended to 6 days.
Highlights
In recent decades, drug delivery controlled by carrier systems has been demonstrated to have successful applications in the diagnosis and treatment of various diseases [1,2,3].Mesostructured spherical nanoparticles are promising intracellular delivery systems for anticancer, immunomodulatory drugs and cell activity modulators, etc. [4,5]
mesoporous hydrophobic silica nanoparticles (MHSs) samples are uniform in size and spherical in shape (Figure 1a,b,d), and their particle size could be adjusted by the amount of CTAB/MTES mole ratio (Table 1)
1429–1627 cm−1 of MHSAC-1 sample was much stronger than that of MHSAC-2 sample as a result of more curcumin loaded in MHSAC-1. All these results demonstrate that curcumin was successfully encapsulated in the as-synthesized MHS-1 samples
Summary
Drug delivery controlled by carrier systems has been demonstrated to have successful applications in the diagnosis and treatment of various diseases [1,2,3].Mesostructured spherical nanoparticles are promising intracellular delivery systems for anticancer, immunomodulatory drugs and cell activity modulators, etc. [4,5]. Drug delivery controlled by carrier systems has been demonstrated to have successful applications in the diagnosis and treatment of various diseases [1,2,3]. Mesostructured spherical nanoparticles are promising intracellular delivery systems for anticancer, immunomodulatory drugs and cell activity modulators, etc. The cellular uptake of nanoparticles by living cells is strongly size-dependent [6]. Small nanoparticle size (≈50 nm) is most efficient for the intracellular delivery [1,7]. The development of a suitable nanostructured carrier system with good biocompatibility and selective delivery of drugs to target cells is the central problem of nanomedicine. Curcumin is a natural bioactive substance, which has been of great interest to researchers due to its wide range of biological activities and pleiotropic therapeutic potential such as antioxidant, antiinflammatory [8,9,10,11,12], antibacterial, antifungal, antiviral, antiprotozoal, and antiparasitic activities [11,13,14,15], but its application has been strictly limited because of its poor solubility in water, short half-life, low bioavailability, and pharmacokinetic profile
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