Azatioprin ilişkili akut pankreatit: Bir olgu sunumu

Abstract

Acute pancreatitis is an important disease. Several drugs have been reported among causes of acute pancreatitis. In this report, we present a case of Crohn disease who developed acute pancreatitis under treatment of azathioprine and budesonide combination. A 30-year-old woman with active Crohn disease was unresponsive to mesalazine and was given azathioprine and budesonide 10 days ago. Diagnosis of acute pancreatitis was established with clinical symptoms, elevated serum amylase level and computed tomography findings of acute edematous pancreatitis. Clinical and biochemical abnormalities resolved after discontinuation of this combination therapy. We restarted budesonide as soon as possible because of the high Crohn disease activity. No new attack occurred after a period of three months. This adverse effect should be kept in mind during the treatment of Crohn disease. Despite drug induced acute pancreatitis usually runs a benign course, one must follow the standardized azathioprine use instructions strictly and consider the possible side effects.