Abstract
The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT 4 receptor antagonists. Optimization of the most potent compound ( 19) by preparing the corresponding oxazino[3,2- a]indole ester afforded 34, which had a pIC 50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
