Abstract
Thalassemia Major is the most common single gene disorder which represents a major health burden worldwide. The available treatment modalities in conventional medicine i.e. blood transfusion (BT) and iron chelation therapies are associated with complications while bone marrow transplantation etc. are out of reach of many. Present study is aimed to highlight the effective role of Ayurvedic medicines i.e. Dhatri Avaleha, Triphaladi Avaleha and Musta-Triphaladi Avaleha in the management of Thalassemia Major. Till date total five clinical researches have been carried out on Thalassemia Major at PG level in the department of Kaumarbhritya at IPGT&RA, Jamnagar. In which a simple random sampling method was followed. Patients were divided into two groups, Group A (Trial group with Ayurvedic drug intervention and BT) and Group B (Control Group with BT and iron chelation therapy). Assessment was done based on the subjective and objective parameters after completion of treatment. The data obtained in clinical studies was analyzed by using suitable statistical tests. The trial drugs were found to be effective on subjective, objective criteria, BT interval and general health status of Thalassemic patients as well as clinically safe.
Highlights
IntroductionThalassemias are a group of inherited disorders of hemoglobin synthesis that results from an alteration in the rate of globin chain production.[1]
Thalassemias are a group of inherited disorders of hemoglobin synthesis that results from an alteration in the rate of globin chain production.[1]. It is an inherited autosomal recessive blood disease where in genetic defect results in reduced rate of synthesis or no synthesis of one of the globin chains that
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Summary
Thalassemias are a group of inherited disorders of hemoglobin synthesis that results from an alteration in the rate of globin chain production.[1]. 1) Thalassemia Major: It is the most severe form of congenital hemolytic anemia. Types: On the basis of clinical manifestations, Thalassemia classified as Thalassemia Major, Thalassemia Intermedia and Thalassemia Minor. It is characterized by transfusion dependent anemia, splenomegaly, bony deformities, growth retardation and hemolytic faces. Survival is depends on regular blood transfusion. 2) Thalassemia Intermedia: It is of intermediate degree of severity that does not require regular blood transfusion. Frequency of Thalassemic gene in Indian population varies from 0-17% in different ethnic groups with average of over 3%. It is prevalent among Gujarati (Lohana, Kachchhi, Bhanushali, Mahera), Punjabi, Sindhi, Agri (Mumbai), Goud Saraswat etc. The Thalassemia centre at GG Hospital, Jamnagar alone has a record of more than 250 Thalassemia Major children who are undergoing the conventional treatment.[3]
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