Abstract
The basal activity level of acetylcholinesterase and choline acetyltransferase was the same in the sciatic nerve of the hibernating and nonhibernating 13-lined ground squirrel. Fast axonal transport of acetylcholinesterase in the sciatic nerve of the nonhibernating squirrel occurred at a rate of 242 mm 24 h and slow transport of choline acetyltransferase was 0.9 mm 24 h . During hibernation, where a significant decrease in metabolic activity occurs, there is a marked reduction in the rate at which these enzymes are transported. The present study supports the concept that the axonal transport of these vital precursors is maintained during hibernation, thus allowing the nerve terminal to regulate transmitter release as well as other trophic properties of the muscle.
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