Axillary lymph nodes enlargement after Sars-CoV-2 vaccine in patients undergoing breast examination: a single-centre experience in 285 women.

Abstract

To assess the incidence of axillary lymphadenopathy over established time ranges after COVID-19 vaccination and lymph node pathologic features (i.e. size increase and qualitative characteristics) in subjects undergoing axillary evaluation during a breast imaging examination. The institutional review board approved this prospective study. women undergoing mammography and breast ultrasound between July and October 2021; information about the COVID-19 vaccine and infection, if any. known metastatic lymphadenopathy. Participants were divided into 5 subgroups according to time between vaccine and imaging: < 6weeks; 7-8weeks; 9-10weeks; 11-12weeks; > 12weeks. Evaluation of axillary lymph nodes was performed with ultrasound. Descriptive statistical analysis was performed. p < 0.05 was considered significant. A total of 285 women were included. Most of the patients underwent Moderna vaccine (n = 175, 61.4%). 63/285 patients had a previous history of breast cancer (22.1%). 13/17 (76.5%) patients with previous COVID-19 infection had no previous history of cancer, whereas 4/17 had a previous history of cancer (p < .001). 41/285 (14.4%) women showed lymphadenopathy, and they were significantly younger (46.9 ± 11.6years) than women with borderline (54.0 ± 11.9years) or no lymphadenopathy (57.3 ± 11.9years) (p < .001). Lymphadenopathy and borderline lymphadenopathy were more frequently observed in the Moderna-vaccinated women and in the subgroup of patients evaluated < 6weeks after vaccination (p < 0.001). The most common pathologic feature was cortical thickening, followed by complete or partial effacement of fatty hilum. A lymphadenopathy within 12weeks after vaccination is a common finding particularly in younger women and after Moderna vaccine and no further assessment should be required.