Axillary Castleman's Disease: A Rare Case Report

Marco Andolfi,Majed Refai,Gaia Goteri,Riccardo Girotto,Nicolò Schicchi

doi:10.23937/2572-3235.1510029

Abstract

Castlemans Disease (CD) is a rare benign lymphoproliferative disorder of uncertain origin which most commonly involves the mediastinum but rarely affects the axilla. We report a case of voluminous axillary unicentral CD, detected due to palpation of a painless mass in the left axilla in a healthy 32-year-old woman.

Highlights

Castleman’s Disease (CD) is a rare non-neoplastic Lymphoproliferative disorder, first described in the 1956 report by Benjamin Castleman [1], who identified a series of solitary hyperplastic mediastinal lymphnodes with small atrophic germinal centers resembling Hassall’s corpuscles of the thymus. most of the CD occurred in the thorax (70%) and commonly involved the mediastinum and the neck (40%), it rarely affected abdomen-pelvis (12%)and axilla (4%)
CD is an uncommon, benign and heterogeneous lymphoproliferative disorder, not sex-linked, and may occur at any age, even though a previous systematic review demonstrated a disparity between Unicentric CD (UCD) and Multicentric CD (MCD)
UCD and MCD differ significantly for histopathogenic type showing that HV-type was found in 78% of patients with UCD vs. 25% of patients with MCD; in contrast Plasma Cell (PC)-type was found in 22% of patients with UCD and 75% of patients with MCD [2]

Summary

Introduction

Castleman’s Disease (CD) is a rare non-neoplastic Lymphoproliferative disorder, first described in the 1956 report by Benjamin Castleman [1], who identified a series of solitary hyperplastic mediastinal lymphnodes with small atrophic germinal centers resembling Hassall’s corpuscles of the thymus. most of the CD occurred in the thorax (70%) and commonly involved the mediastinum and the neck (40%), it rarely affected abdomen-pelvis (12%)and axilla (4%). A careful surgical excision was performed with uneventful postoperative course and was dismissed after five postoperative days. Castleman’s Disease (CD) is a rare non-neoplastic Lymphoproliferative disorder, first described in the 1956 report by Benjamin Castleman [1], who identified a series of solitary hyperplastic mediastinal lymphnodes with small atrophic germinal centers resembling Hassall’s corpuscles of the thymus.

Results

Conclusion