Axially chiral N-heterocyclic carbene gold(I) complex catalyzed asymmetric Friedel–Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes with indole derivatives

Jinming Yang,Rui Zhang,Wenfeng Wang,Zhen Zhang,Min Shi

doi:10.1016/j.tetasy.2011.12.004

Axially chiral N-heterocyclic carbene gold(I) complex catalyzed asymmetric Friedel–Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes with indole derivatives

Jinming Yang, Rui Zhang + Show 3 more

https://doi.org/10.1016/j.tetasy.2011.12.004

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Journal: Tetrahedron: Asymmetry	Publication Date: Dec 1, 2011
Citations: 36

Affiliation: East China University of Science and Technology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

#Indole Derivatives #Friedel Crafts + Show 8 more

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Abstract

A class of axially chiral NHC–Au(I) complexes has been applied to the asymmetric Friedel–Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes 14 with indole derivatives 15, affording the corresponding Friedel–Crafts and intramolecular cyclization products 16 in good yields and with moderate ee values under mild conditions.

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