Abstract
Currently, one of the most dynamic areas in organic synthesis is the asymmetric construction of molecules with quaternary carbon stereocenters, that is, carbon centers with four different alkyl substituents.[1] The state-of-the-art in this field is the asymmetric construction of these stereocenters in acyclic systems.[2] In the last few years, we have been involved in the development of synthetic strategies that have led to the formation of these desired fragments, but we have focused on the concomitant creation of several carbon–carbon bonds in a one-pot operation.[3] Our method consists of a carbometalation reaction of various α-hetero-substituted functionalized alkynes[4] followed by a zinc homologation reaction[5] through the use of a zinc carbenoid, formed in situ,[6] and then an allylation reaction of carbonyl compounds (Scheme 1).
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