Abstract
BackgroundMyopia is a global public health issue. Controlling myopia progression is a primary focus of myopia studies today. Peripheral retinal myopic defocus is considered the mechanism for reduced myopia progression in orthokeratology studies. The topographic change in the front corneal surface after laser refractive surgery and orthokeratology procedures may appear similar. The purpose of this study was to explore the role of myopic laser ablation on axial length (AL) growth.MethodsMyopic patients who underwent monocular excimer laser refractive surgery first in one eye and then in another eye several years later because of myopia occurrence or myopia progression were recruited. The axial length elongation and refraction (spherical equivalent) between the two eyes were observed and compared.ResultsA total of 8 myopic patients were enrolled in the study. The AL increased from 24.52 ± 0.96 mm to 24.68 ± 1.03 mm but without significance (T = 1.49, P > 0.05) in the ablated eyes. The AL increased significantly from 23.73 ± 0.91 mm to 24.26 ± 0.95 mm in the nonablated eyes (T = 6.76, P < 0.001). The AL elongation of the ablated eyes with 0.16 ± 0.30 mm growth was significantly lower than that of the nonablated eyes with 0.53 ± 0.32 mm growth (T = 8.98, P < 0.001). The spherical equivalent (SE) increased significantly in the ablated eyes (− 0.59 ± 0.21 (D), T = 6.36, P < 0.001) and in the nonablated eyes (− 0.97 ± 0.55 (D), T = 4.91, P < 0.01), and the difference between the two eyes was significant (T = 3.05, P < 0.05).ConclusionsThe inhibitory effect of myopic laser ablation on AL elongation reported in the limited case studies argues for animal research on its efficacy as a new intervention for myopia progression.
Highlights
Myopia is a global public health issue
Many studies have shown that topographic changes in the front corneal surface after laser refractive surgery and orthokeratology procedures may appear similar [12, 13]
The study met all standards for ethical approval in China, and the protocol was approved by the institutional board at Jing-An District Center Hospital
Summary
Myopia is a global public health issue. Controlling myopia progression is a primary focus of myopia studies today. Peripheral retinal myopic defocus is considered the mechanism for reduced myopia progression in orthokeratology studies. The topographic change in the front corneal surface after laser refractive surgery and orthokeratology procedures may appear similar. The purpose of this study was to explore the role of myopic laser ablation on axial length (AL) growth. Many studies have shown that topographic changes in the front corneal surface after laser refractive surgery and orthokeratology procedures may appear similar [12, 13]. We hypothesize that myopic refractive corneal surgery can play a role similar to orthokeratology contact lenses (OK lenses) in slowing myopia progression. The aim of the study was to explore the role of myopic refractive surgery in slowing myopia progression
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