Abstract
Avoiding Unnecessary Antibiotic Exposure in Premature Infants
Highlights
Antibiotic treatment is common among premature infants given their significant risk of earlyonset sepsis (EOS) and its related consequences, but prolonged antibiotic exposure in the absence of proven infection is associated with significant morbidity and mortality.[1]
Flannery et al[2] observed that approximately 1 in 4 very low-birthweight (VLBW) infants and 1 in 3 extremely low-birth-weight (ELBW) infants in their study cohort were exposed to prolonged early antibiotic therapy
A recent retrospective cohort study assessed early antibiotic treatment in VLBW infants who were deemed to be at low risk for EOS.[5]
Summary
Antibiotic treatment is common among premature infants given their significant risk of earlyonset sepsis (EOS) and its related consequences, but prolonged antibiotic exposure in the absence of proven infection is associated with significant morbidity and mortality.[1]. Flannery et al[2] observed that approximately 1 in 4 VLBW infants and 1 in 3 ELBW infants in their study cohort were exposed to prolonged early antibiotic therapy.
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