Avoiding Bleeding Complications: Heparin Bolus or Weight Based – Does it Make a Difference Between the Sexes?

Abstract

It has been determined that women have more adverse drug reactions with cardiovascular medication than men, as result of different pharmacokinetics and pharmacodynamics.1 However, there are few data about the differences in the effect of heparin in males and females specifically in non-cardiac arterial procedures (NCAP). In the current issue, Roosendaal et al. mean to expand our understanding.2 The study is a retrospective analysis of a prospective multicentre cohort. The authors investigated all patients undergoing elective NCAP using heparin and activated clotting time measurements (ACT; target of 200–250 s).