Avoidance of Whitening of Brownadipose Tissue (BAT/Beige Adipose Tissue (BeAT)-as an Innovative Target of Obesity/Ageing Prevention-A Mini Review

Abstract

Whereas we have been working regarding the browning of WAT for practically last 2 decades in obesity research, whitening of BAT as an obesity-correlated complication possessing metabolic along with health aspects has not got considerable importance. Here our aim has been to focus on why there is an escalation of BAT whitening which by itself becomes a considerable cause of obesity and its complications. Here we have paid attention to Natural factors, High Fat Diet, Ageing, part of nicotine, thermo neutrality, Serotonin, Glucocorticoids obesogens, Dechlorane plus endocrine disrupting chemicals (EDCs), like wide spectrum of consumer products, like tobacco, flame retardants, as well as pesticides which we are exposed in common day to day life apart from consumption of nicotine in the prenatal or lactation exposure to the offspring as well as the origin of chronic diseases beyond infancy. Furthermore our concentration has been over how autophagy, inflammation, along with dysfunctional angiogenesis “vascularization” are central events involved in BAT/beige AT whitening of these we have detailed role of VEGF-A besides role of Bevacizumab its antibody , capillary rarefaction as well as hypoxia in a little detail. Ageing is a natural event. When BAT starts receding specifically in females direct association of BAT with reproduction is seen & apparently FSH antibody is acknowledged to revert post menopause and post-andropause diminished metabolic rate that is associated with escalated visceral adiposity in addition to escalate longevity. Moreover, recently the group of Vatner, et al. have discovered that interference with the Regulator of G protein signaling14 (RGS14) in mice escalates healthy lifespan, modulation by escalated BAT. Thus RGS14 seems to be a target that’s hampering apparently escalated longevity in addition to BAT. Capillary rarefaction impacts numerous organs .Hence avoidance of smoking in pregnancy might be a significant long term factor in preventing chronic diseases beyond infancy specifically in males in view of females get protected by estrogen. Thus greater focus is needed to avoidance of whitening of BAT to combat the epidemic of obesity. Too much misuse of dexamethasone prescription needs to be avoided since post covid era