Abstract
An important issue for the origins of life is ensuring the accurate maintenance of information in replicating polymers in the face of inevitable errors. Here, we investigated how this maintenance depends on reaction kinetics by incorporating the elementary steps of polymerization into the population dynamics of polymers. We found that template-directed polymerization entails an inherent error-correction mechanism akin to kinetic proofreading, potentially generating the tolerance of long polymers to an error catastrophe at the cost of a slow polymerization process. As this mechanism does not require enzymes, it is likely to operate under broad prebiotic conditions.
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