Abstract

BackgroundUndesirable outcomes in health care are associated with patient harm and substantial excess costs. Coarctation of the aorta (CoA), one of the most common congenital heart diseases, can be repaired with stenting but requires monitoring and subsequent interventions to detect and treat disease recurrence and aortic wall injuries. Avoidable costs associated with stenting in patients with CoA are unknown.MethodsWe developed an economic model to calculate potentially avoidable costs in stenting treatment of CoA in the United Kingdom over 5 years. We calculated baseline costs for the intervention and potentially avoidable complications and follow-up interventions and compared these to the costs in hypothetical scenarios with improved treatment effectiveness and complication rates.ResultsBaseline costs were £16 688 ($25 182) per patient. Avoidable costs ranged from £137 ($207) per patient in a scenario assuming a 10% reduction in aortic wall injuries and reinterventions at follow-up, to £1627 ($2455) in a Best-case scenario with 100% treatment success and no complications. Overall costs in the Best-case scenario were 90.2% of overall costs at Baseline. Reintervention rate at follow-up was identified as most influential lever for overall costs. Probabilistic sensitivity analysis showed a considerable degree of uncertainty for avoidable costs with widely overlapping 95% confidence intervals.ConclusionsSignificant improvements in the treatment effectiveness and reductions in complication rates are required to realize discernible cost savings. Up to 10% of total baseline costs could be avoided in the best-case scenario. This highlights the need to pursue patient-specific treatment approaches which promise optimal outcomes.

Highlights

  • Undesirable outcomes in health care are associated with patient harm and substantial excess costs

  • We developed an economic model to calculate the expected costs associated with stenting for Coarctation of the aorta (CoA) in the United Kingdom on a per patient basis

  • We summarized the results of probabilistic sensitivity analysis (PSA) using the mean value of the 1000 iterations and its 95% confidence interval (CI)

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Summary

Introduction

Undesirable outcomes in health care are associated with patient harm and substantial excess costs. Coarctation of the aorta (CoA), one of the most common congenital heart diseases, can be repaired with stenting but requires monitoring and subsequent interventions to detect and treat disease recurrence and aortic wall injuries. Avoidable costs associated with stenting in patients with CoA are unknown. Costs associated with undesirable outcomes, including treatment complications and reinterventions, can be quantified as avoidable costs. Implementation of a stent is an effective option to repair the obstructed site of the aorta, yet patients are still at risk of experiencing serious complications while undergoing treatment, and outcomes at follow-up show scope for significant improvement. Recurrent CoA and aortic wall injuries contribute to a reintervention rate after stenting of approximately 14% at follow-up [9]

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