Abstract
Publisher Summary Independent isolates of avian leukosis virus (ALVs) cause different incidences of a variety of different diseases. Most isolates cause a relatively high incidence of one form of disease and a low incidence of other neoplasias. This chapter reports on oncogenicity tests that examine the role of the env gene and the U3 region in determining the oncogenic potential of ALVs that cause nonacute diseases. To examine the oncogenic potential of defined regions of the ALV genome, the recombinants of oncogenic and nononcogenic ALVs were tested for their oncogenic potential. In the tests undertaken to define the role of the envelope gene in oncogenesis, the recombinants of the oncogenic viruses Rous-associated virus-1 (RAV-1) and Rous-associated virus-2 (RAV-2) with viral information encoded by the nononcogenic endogenous viruses that reside at ev3 and ev9 were tested for their oncogenic potential. The results of these tests indicate that (1) ALV envelope antigens do not determine oncogenic potential and (2) U3 sequences determine the ability to induce a low incidence of a variety of cancers. The region of the ALV genome that causes a high incidence of a specific form of disease was not resolved.
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