Avian influenza A(H7N9) and (H5N1) infections among poultry and swine workers and the general population in Beijing, China, 2013-2015.

Peng Yang,Chunna Ma,Weixian Shi,Yang Pan,Quanyi Wang,Yimeng Liu,Jiachen Zhao,Daitao Zhang,Ying Sun,Shujuan Cui,Guilan Lu,Xiaomin Peng

doi:10.1038/srep33877

Peng Yang, Chunna Ma + Show 10 more

Open Access

https://doi.org/10.1038/srep33877

Copy DOI

Abstract

Although several studies have reported seroprevalences of antibody against avian influenza A(H7N9) virus among poultry workers in southern China, results have varied and data in northern China are scarce. To understand risks of H7N9 and H5N1 virus infections in northern China, a serological cohort study was conducted. Poultry workers, swine workers and the general population in Beijing, China, were evaluated through three surveys in November 2013, April 2014 and April 2015. The highest seroprevalence to H7N9 virus among poultry workers was recorded in the April 2014 and April 2015 surveys (0.4%), while that to H5N1 clade 2.3.4 or clade 2.3.2.1 virus was noted in the April 2014 survey (1.6% and 0.2%, respectively). The incidence of H7N9 virus infections among poultry workers (1.6/1000 person-months) was significantly lower than that of H5N1 clade 2.3.4 infections (3.8/1000 person-months) but higher than that of H5N1 clade 2.3.2.1 infections (0.3/1000 person-months). Compared with the general population, poultry workers were at higher risk of contracting H7N9 virus (IRR: 34.90; p < 0.001) or H5N1 clade 2.3.4 virus (IRR: 10.58; p < 0.001). Although risks of H7N9 and H5N1 virus infections remain low in Beijing, continued preventive measures are warranted for poultry workers.

Highlights

In March 2013, human infections with a novel avian influenza A(H7N9) virus were discovered in Southeast China[1,2]
Previous serological studies on H7N9 virus infection focused on southern China[13,14,15], with no serological evidence reported from northern China
To understand the risk of human infections with H7N9 and H5N1 viruses in northern China, a serological cohort study was undertaken that surveyed poultry workers, swine workers and the general population in Beijing, China, between November 2013 and April 2015

Summary

Introduction

In March 2013, human infections with a novel avian influenza A(H7N9) virus were discovered in Southeast China[1,2]. To understand the risk of human infections with H7N9 and H5N1 viruses in northern China, a serological cohort study was undertaken that surveyed poultry workers, swine workers and the general population in Beijing, China, between November 2013 and April 2015.

Results

Conclusion