Abstract

Exposure of rats to a novel substance (.1% sodium saccharin) was paired with 0, .25, .5, 1.0, 2.0, and 4.0 mg/kg of Δ9-THC (tetrahydrocannabinol) for 1, 6 or 12 days. In a subsequent test, all groups showed a decreased preference for saccharin as the dosage of THC was increased. The results indicated that THC is aversive in multiple as well as single injections.

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