Avascular Necrosis in Children with Acute Lymphoblastic Leukemia

Abstract

This study describes the prevalence and demographics of avascular necrosis (AVN) in children with acute lymphoblastic leukemia (ALL). With improving survival of ALL patients on modern chemotherapy regimens, an increasing number of children with AVN will be presenting to orthopaedists. From 1991 to 1996, 202 patients were treated for ALL at a major tertiary pediatric cancer referral center. Eight patients (4.0%) subsequently developed AVN at an average of 30.0 months after beginning chemotherapy. A total of 27 documented joints were involved, with an average of 3.4 joints affected per patient diagnosed with AVN. The subset of patients with high-risk ALL who underwent an aggressive chemotherapy protocol was particularly susceptible to developing AVN. Six of 58 high-risk ALL patients (10.3%) developed AVN at an average of 18.5 months. As ALL patients now frequently survive into adulthood, orthopaedists will be increasingly called on to manage AVN affecting multiple joints in children and young adults.