Abstract
Butter extracted from bacuriseeds (Platonia insignis) is widely used as a raw material in the formulation of cosmetic products. Furthermore, with the advances in research, other biological properties beneficial to health have been investigated. Therefore, tests to assess the safety for consumption are essential. This study aimed to evaluate in vitroand in vivotoxicity parameters of industrialized butter obtained from bacuriseeds (MIB). Cytotoxic activity was performed using the MTT assay in murine macrophages and in sheep blood erythrocytes and the acute oral toxicological evaluation in vivowas performed using the Fixed Dose Test. In the in vitroassays, a concentration-dependent reduction in cell viability was observed by evaluating the mitochondrial activity, with a mean cytotoxic concentration value (CC50) equal to 124.036 μg/mL and low hemolytic activity, since MIB promoted less than 10% hemolysis at the highest concentration tested (800 μg/mL), and it is not possible to determine the average hemolytic concentration. In the in vivotest, no deaths or alterations were observed in the evaluated clinical and behavioral parameters, as well as in the serum biochemical parameters, in the relative weight and in the macroscopic evaluation of the organs. All these results demonstrate an adequate safety profile, enabling the performance of subchronic toxicity tests, in order to allow the safe exploration of the therapeutic potential of this product.
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