Abstract
AIMS: To investigate the effects of chronic ethanol consumption and alcohol detox on macroscopic gastric lesions in rats. METHODS: This is an experimental study in which 18 adult male rats (Rattus norvegicus) of the Wistar strain, with 40 days of life were divided into three randomized groups with six animals each: Control Group (CT), Detoxicated Group (DE) and Alcohol Group (AC). The AC animals have been subjected to an experimental model termed as chronic alcoholics, in which, after a period of adaptation, they received ethanol as the only liquid food available until completion of 13 weeks of the experiment. The DE was subjected to the same protocol as the AC, however, after six weeks of alcohol consumption, the animals were subjected to the alcohol detoxification process. At the end of the experiment, the stomach of the three groups of animals were collected in order to investigate the presence of gastric lesions. RESULTS: The animals in the CG showed no lesions. The animals in DE exhibited a larger number of lesions in comparison to the AC (44±3.7 and 21±0.3 respectively). Macroscopic examination of the animal’s stomachs indicates that the animals in the DE were those with the highest injury rate in the gastric mucosa. CONCLUSIONS: Ethanol consumed chronically or after alcohol detoxification triggered gastric lesions in AC and DE, but sharply in the group submitted to detoxification, which can characterize a possible synergism between ethanol consumption and alcohol detox post-stress in the pathogenesis of gastric ulcer.
Highlights
To investigate the effects of chronic ethanol consumption and alcohol detox on macroscopic gastric lesions in rats. This is an experimental study in which 18 adult male rats (Rattus norvegicus) of the Wistar strain, with 40 days of life were divided into three randomized groups with six animals each: Control Group (CT), Detoxicated Group (DE) and Alcohol Group (AC)
The AC animals have been subjected to an experimental model termed as chronic alcoholics, in which, after a period of adaptation, they received ethanol as the only liquid food available until completion of 13 weeks of the experiment
The DE was subjected to the same protocol as the AC, after six weeks of alcohol consumption, the animals were subjected to the alcohol detoxification process
Summary
André Luiz Thomaz de Souza[1], Renato de Oliveira Horvath[2], Fábio de Souza Terra[3], José Antônio Dias Garcia[4], Ana Maria Duarte Dias Costa[5], Evelise Aline Soares[6]. Objetivos: Investigar os efeitos do consumo crônico de etanol e da desintoxicação alcoólica sobre o aspecto macroscópico em lesões gástricas em ratos. Os animais do grupo AC foram submetidos a um modelo experimental denominado alcoolista crônico, em que, após um período de adaptação receberam etanol como único alimento liquido disponível até completar 13 semanas de experimento. Os animais do grupo DE foram submetidos ao mesmo protocolo que o grupo AC, no entanto, ao completarem seis semanas de consumo alcoólico, foram submetidos ao processo de desintoxicação alcoólica. A análise macroscópica dos estômagos indica que os animais do grupo DE foram os que apresentaram maior índice de lesões na mucosa gástrica.
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