Abstract
PURPOSE: Observe the effects of corneal intrastromal injection of biguanide at 0.02%, 0.1% and 0.5% in rabbits’ eyes. METHODS: Doble blind prospective study. 8 rabbits were used, randomly identified and divided into 4 groups, with 2 rabbits each, with the administration of 0.2 ml of the drug via intrastromal, in the right eye. The first group received biguanide at a concentration of 0.02%, the second one at 0.1%, the third at 0.5% and the fourth group (control) was given a [...]
Highlights
One rabbit from each group was sacrificed on the third day and the remaining rabbits on the tenth day after the drug injection and had its right eyes enucleated and submitted to histopathological analysis
The rabbit sacrificed on the third day after the drug injection at 0.1% presented mild inflammatory infiltrate with neutrophils and eosinophils, on the tenth day there was stromal necrosis, vascularization and intense infiltrate
Biguanide when used at concentrations of 0.1% and 0.5% may cause adverse reactions in the rabbit's cornea, which arouses the necessity of further studies with a larger sample to confirm the findings
Summary
Um dos coelhos de cada grupo foi sacrificado no terceiro dia e o outro no décimo dia após a injeção da droga e tiveram os olhos direitos enucleados e submetidos a exame histopatológico. O coelho sacrificado no terceiro dia após a injeção da droga a 0,1% apresentou infiltrado inflamatório discreto com neutrófilos e eosinófilos, porém no décimo dia houve necrose estromal, vascularização e infiltrado intenso. Figura 1: fotografia do corte histopatológico do terceiro dia após a injeção de biguanida a 0,02% (coelho do primeiro grupo).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
