Abstract
Abstract Acute myeloid leukemia (AML) is a neoplasm ofhematopoietic tissue characterized by abnormal proliferation ofmyeloid lineage progenitor cells, reflecting in changes in the peripheralblood including anemia, thrombocytopenia and leukocytosis at thecost of immature myeloid cells. With the advent ofimmunophenotyping by flow cytometry (FC) employingmonoclonal antibodies (MoAb), the diagnosis of these leukemiashas become more accurate. The aim of this study was to diagnosecases of AML based on immunophenotyping and morphologicalclassification using the criteria of the French-American-British group(FAB) employing a MoAb panel in samples of bone marrow aspiratefrom 179 AML patients, in order to establish patterns of antigenexpression for the different FAB subtypes. Additionally, thefrequencies of cases with aberrant phenotypes were evaluated aswere the clinical criteria. All patients were referred to the Hemocentrodo Rio Grande do Norte – Hemonorte. Of the AML patients studied, Dissertacao de mestrado apresentada ao programa de Pos-Graduacao em Ciencias Farmaceuticas (PPgCFAR) da Universidade Federaldo Rio Grande do Norte (UFRN).Universidade Federal do Rio Grande do Norte (UFRN), Centro de Ciencias da Saude (CCS), Programa de Pos-Graduacao emCiencias Farmaceuticas – PPgCFAR – Natal-RN.
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