Abstract
Objective: Evaluate the impact of adenotonsillectomy on the humoral immune system in children, according to its surgical criteria. Methods: A total of 69 children scheduled for adenotonsillectomy were included in this study and subsequently separated into three groups according to the surgical criteria (infectious, hypertrophic and both). The levels of IgA, IgG, IgM, C3, and C4 were measured in blood samples collected in these patients before and 6 months after surgery. Results: The levels of IgG, IgA and IgM in children undergoing adenotonsillectomy showed a significant decrease in the postoperative period, while levels of C3 were significantly higher. Regarding the division according to surgery criteria there was a significant reduction in IgA in all groups, while in children operated due to obstructive criteria there was still a significant increase in C4 and decrease in IgG. In children with both surgical indications were also observed a significant decrease in IgM. Conclusion: The present study demonstrates that adenotonsillectomy has a significant impact on the serum levels of immunoglobulins and complement, and that this impact is variable depending on the surgical indication. However, immunoglobulins and complement values remained within the reference values for ages, showing that this procedure does not compromise immune function of children, regardless of age.
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