Abstract
Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p
Highlights
Denture associated stomatitis is a high-prevalence disease related to the Candida presence (60 to 100% of those who wear dentures), deficient oral and denture hygiene, high roughness of resin, and trauma[1]
The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness
Within the limitations of this study, it was concluded that the use of a solution composed by distilled water and 0.5 wt.% of PHMGH for 5 min was effective as a disinfectant agent against mature biofilm of C. albicans, maintaining acceptable roughness and flexural strength
Summary
Denture associated stomatitis is a high-prevalence disease related to the Candida presence (60 to 100% of those who wear dentures), deficient oral and denture hygiene, high roughness of resin, and trauma[1]. Commercial mouthwashes such as those disinfectants composed by alcohols, sodium hydroxide, and sodium benzoate, and those without alcohol but compose by chlorhexidine digluconate, cetylpiridinium chloride, phosphoric acid, and sodium benzoate were previously tested in acrylic resins and negatively affected microhardness and surface roughness[15,16] In this context, disinfectant solutions that do not compromise physical properties and surface texture of acrylic resins are necessary to reduce the biofilm formation[17]. Conclusion: Within the limitations of this study, it was concluded that the use of a solution composed by distilled water and 0.5 wt.% of PHMGH for 5 min was effective as a disinfectant agent against mature biofilm of C. albicans, maintaining acceptable roughness and flexural strength
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