Avaliação de derivados sintéticos (triazóis dissubstituídos) contra ações tóxicas de venenos de serpentes

Abstract

Accidents involving venomous animals are a health public problem in Brazil and worldwide, as well. Snake bite results in hemorrhage, hemolysis, necrosis, coagulation disorders, neurotoxicity and death. In Brazil, current therapy recommended by the Ministry of Health is performed by the intravenous administration of heterologous antivenom serum, be monovalent or polyvalent, produced by hyper immunization in equines. However, therapy may induce side effects to patients and it does not prevent efficiently local effects (as tissue necrosis), leading deformities and/or amputation of the affected limb of the victim. Besides that, snake bites may become a socioeconomic problem and an inability of victims to work. Therefore, the search for new molecules and treatments are need as an alternative to aid serum therapy to neutralize the toxic activities of snake venom. Literature has described antivenom effect of molecules derived from natural sources, as plants. However, such investigation on molecules obtained from organic synthesis is poorly investigated. Thus, the aim of this study was to analyze some derivatives of sulfonamides and dissubstituted triazoles to inhibit some in vivo (hemorrhage and edema) and in vitro (hemolysis, coagulation and proteolysis) toxic activities of Lachesis muta and Bothrops jararaca snake venom, since these species produce the highest severity and frequency of accidents in Brazil, respectively. Moreover, this work also aims to rationalize the design of new organic compounds to be used as prototypes to develop molecules able to neutralize toxic activities of venoms to replace, and even use them as a complement to serum therapy. As a result, it was possible to observe that the synthetic derivatives inhibited the toxic activities of L. muta and B. jararaca venom, but with different potencies.