Abstract
Castor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation. KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.
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