Abstract
This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measured by the Kleihauer-Betke test (K-B). The rosette test was positive in 22 cases (6.4%). In five of these cases, K-B did not show fetomaternal hemorrhage (a 1.45% false-positive rate for the rosette test), and in one case the test was inconclusive. There were 8 cases with FMH < 10 ml (2.3%), 6 cases with FMH from 10 to 30 ml (1.7%), and two cases with FMH > 30 ml (0.58%), requiring a supplementary dose of anti-D. The study concludes that following the rosette test, additional evaluation of FMH using a quantitative test was unnecessary in 93.6% of the cases.
Highlights
Hemorragia feto-materna é a transferência de sangue fetal para o compartimento intravascular materno, devido à ruptura na membrana vásculo-sincicial da placenta 1
This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with antiD immunoglobulin
The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was measured by the Kleihauer-Betke test (K-B)
Summary
Hemorragia feto-materna é a transferência de sangue fetal para o compartimento intravascular materno, devido à ruptura na membrana vásculo-sincicial da placenta 1. Nosso estudo teve por objetivo avaliar o volume de sangue fetal transferido para circulação materna nas puérperas em que se impõem a profilaxia da aloimunização Rh com imunoglobulina anti-D, a fim de detectar casos de hemorragia feto-materna excessiva e contribuir para ministração da dose mais adequada, bem como fornecer subsídios para uma comparação crítica do programa brasileiro de profilaxia da aloimunização RhD.
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