Abstract
Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [ 14C]iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N-isopropyl- p-[ 125I]iodoamphetamine (IMP) was estimated as an index of CBF in normal rats and compared with the quantitative CBF value measured using [ 15O]H 2O and dynamic PET scan. A good correlation between the two values was obtained. The results indicate that DUR of [ 125I]IMP at 5 min after injection in rats is a useful and practical indicator of CBF since neither arterial blood sampling nor metabolite correction is necessary.
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