Availability and Use of Vaccines against COVID-19 in Pregnancy

Saugat Koirala,Binay Kumar Chaudhary,Smriti Pant

doi:10.3126/nmmj.v2i2.41285

Saugat Koirala, Binay Kumar Chaudhary + Show 1 more

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https://doi.org/10.3126/nmmj.v2i2.41285

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Abstract

Pregnant women when infected with SARS-CoV-2 infection are more at risk of having severe outcomes including ICU admission, adverse cardiac and thromboembolic events and preterm delivery. Immunization in pregnancy has certain ethical dilemmas and vaccination seems to be challenging. Preliminary data regarding the use of mRNA based vaccines against this virus in pregnant women is promising. Recently, RCOG and WHO have widened the scope of use of vaccines among pregnant women against COVID-19. Similarly, ACOG has also given the go-ahead to the use of two mRNA based and one viral vector based vaccine in pregnant women. The scope of vaccination among pregnant and lactating women being realized in developed part of world is a promising prospect in prevention of COVID-19 infections. However, developing nations require attention from private stakeholders, health and social care organizations to ensure right of health for all.

Highlights

The SARS-CoV-2 (Corona Virus) infection was first identified in 2019 from a pneumonia patient in Wuhan, China and since has rapidly spread all over the world [1]
This article is one of the first ones to include the latest preliminary findings of the effects of vaccination in the pregnancy and lactation. For writing this Narrative Review article, Google, Google Scholar, Pub Med and online news portals were searched by using various combination of the following terminologies: “COVID-19”, “Corona Virus”, “SARS-CoV-2 “, “Pregnancy”, “Lactation”, “Vaccine”, “Vaccination”, “Immunization”, “Pfizer”, “Moderna”, “Janssen”, “Oxford”, “AstraZeneca”, “Newborn”, “CDC”, “Food and Drug Administration (FDA)”, “ACOG”, “Royal College of Obstetrics and Gynecology (RCOG)”, “WHO”, “Findings” and “Outcomes”
We screened all the articles that we found from the search, with the aim of including articles that had information about different types of vaccines against COVID-19 and their use in pregnancy

Summary

Introduction

The SARS-CoV-2 (Corona Virus) infection was first identified in 2019 from a pneumonia patient in Wuhan, China and since has rapidly spread all over the world [1]. Renal failure, adverse cardiac outcome, thromboembolic events are other complications in those gravid population who get infected with Corona Virus infection [5]. Physiological changes in pregnancy along with immunologic alterations add to the distress in the gravid population when they get infected with this virus [6, 7]. Prevention of such infection with active immunization and prophylaxis is of as much importance if not more than the antiviral therapy [7]. The issues of vertical transmission of COVID-19 infection and the potential of vaccine use in its prevention lags adequate research [10]. This article is one of the first ones to include the latest preliminary findings of the effects of vaccination in the pregnancy and lactation

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