AV-node isolation in atrial fibrillation vs AV-node ablation by pace and ablate strategy

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Introduction AV-node ablation (AVNA) is a common therapy option for rate control strategy of permanent atrial fibrillation. However, this therapy has numerous side-effects as bundle branch blocks and absence of escape rhythm. We have invented a new technique that isolates the AV node instead of ablation. Methods Our study includes 60 patients with 40 being treated with AVNA and 20 being treated with AV-node isolation (AVNI). In AVNI patient´s AV-node region was mapped using 3D navigation system. Ablation was performed around the previously mapped HIS-cloud regions isolating the atrium from the AV-node. In all cases in AVNI group ablation was performed with irrigated tip ablation catheter. Procedure time, ablation points, fluoroscopy time and total DAP, escape rhythm and delta QRS among other data were measured and compared in these two methods. Statistical analysis was performed by SPSS software 27.0. Results No complications appeared in this study. In the AVNI group more ablation points were used (p < 0.01) but there was no significant difference in total procedure time (p = 0.730). With AVNI highly significantly less fluoroscopy time (1.4 vs. 4.7 minutes) and total DAP (40.75 vs. 382.85 µGym²) was achieved (p < 0.01). Moreover, the median change in QRS width was 0 ms in the AVNI group vs. 26 ms in the AVNA group (p < 0.01). Immediately postoperative the escape rhythm of the AVNI group was significantly higher than in the AVNA group (MRang = 37.38 vs. MRang = 27.06, p = 0.023). Conclusion AV-node isolation using 3D navigation mapping system is a safe and effective alternative to classic AVNA procedure with less radiation exposure and potential preservation of escape rhythm, which is a major benefit in case of a pacemaker failure. Figure 1. 3D Navigation pictures after successful AVNI with NavX-System (left panel) and CARTO 3-System (right panel). His cloud with yellow points. The Tricuspid annulus could be defined with different color (green on the left panel) or with the tag points (white points on the right panel). Modified left lateral to posterior view. Abstract Figure.