Abstract
The heart pumps blood into circulation against the mechanical load from vascular resistance andactively regulate the cardiac muscle contraction to compensate for load changes. To decipher theunderlying mechanisms, we developed a Cell-in-Gel technology to investigate the mechano-chemo-transduction (MCT) mechanisms that transduce mechanical load to biochemical signalsto regulate the cardiomyocyte contraction. Our experimental studies reveal that MCT regulateseach of the dynamic systems involved in cardiac excitation-Ca2+ signaling-contraction (E-C)coupling.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
