Abstract
A simplified avian kidney model was used to assess renal plasma flow (RPF) at normal (100–110 mmHg) or unilaterally reduced (40–50 mmHg) renal arterial perfusion pressure (RAPP) in domestic fowl with ambient (AMBIENT group) or restricted (RESTRICTED group) renal portal flow. Direct measurement of para-aminohippuric acid (PAH) extraction efficiencies (EPAH) allowed avian RPF to be calculated from the clearance of PAH (CPAH). EPAH was unaffected by RAPP, thereby validating the use of PAH to estimate RPF during experimental hemodynamic manipulations. CPAH and RPF were unaffected by RAPP in the AMBIENT group (“perfect” autoregulation), but decreased significantly compared with contralateral kidney values during reduction of RAPP in the RESTRICTED group. Urine flow and glomerular filtration rates (GFR) were reduced unilaterally along with RAPP, regardless of the portal perfusion status. The renal portal system contributes to overall RPF autoregulation in domestic fowl, helping to maintain constancy of renal blood flow even after RAPP is reduced well below the GFR autoregulatory limit.
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