Abstract
Cell renewal in the gastric fundie mucosa of fasting dogs was studied autoradiographically, after intravenous injection of tritiated thymidine. The proliferative population in the gastric pits was delimited, using as reference the limit between foveolar and mucous neck cells. The S-phase duration was measured on the curve of the labelled mitoses and, using the labelling index, the turnover time was calculated. Repeated daily biopsies permitted observation of cell migration. Since the turnover time in our experimental animals was very low, the possible influence of their fasting state was discussed. © 1971 S. Karger AG, Basel.
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