Abstract
Although islands of viable muscle are found in areas of myocardial infarction, standard techniques for studying myocardial collateral circulation have not satisfactorily demonstrated a similar heterogeneous pattern of tissue blood flow. In the present study, a non-uniform distribution of myocardial blood flow has been graphically demonstrated in dogs after experimental coronary artery occlusion by use of a macroscopic autoradiographic technique. Patchy blood flow was found in areas of both brief and prolonged ischaemia. These autoradiographic findings were confirmed by similar studies using a fluorescent dye.
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