Abstract

Quantitative autoradiography has shown that initial food-motivated conditioning results in an increase in 3H-phenylalanine incorporation into cytoplasmic proteins of rat hippocampal neurons. After 3 daily conditioning trials, the incorporation returned to an active control (pseudoconditioning) level while after 6 daily trials, the incorporation was decreased. No changes were revealed in the cells of hippocampal perineuronal glia. Four hours after a footshock-motivated passive avoidance trial, incorporation of 3H-phenylalanine was increased both in the neurons and in their perineuronal glia of rat hippocampus. By the time of a consolidation of this conditioning, such increase still remained in the glia but disappeared in the neurons. Subsequently, no changes were found in the hippocampal neurons or in their perineuronal glia. An importance of the emotional background is outlined for a participation of glial cells in learning-induced metabolic changes in the nervous system.

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