Autoradiographic analysis of RNA synthesis by sympathetic neurons in a population containing a reduced number of cells

Abstract

An autoradiographic analysis was made of the dynamics of synthesis of nuclear and cytoplasmic RNA by sympathetic neurons of presenile mice subjected to partial desympathization during the first days after birth by injection of guanethidine. Neurons from a population with a sharply reduced number of cells have lower rates of migration of newly synthesized RNA from nucleus into cytoplasm than in the corresponding age control. Neurons of partially desympathized animals of infantile, juvenile, and presenile ages are no larger than the cell bodies of control mice.