Abstract
Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow–Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.
Highlights
Neurological complications of cancer are protean and can involve any area of the neuroaxis through direct local invasion or distant paraneoplastic effects
We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy
NL refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system (CNS) or systemic lymphoma
Summary
Neurological complications of cancer are protean and can involve any area of the neuroaxis through direct local invasion or distant paraneoplastic effects. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.
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