Abstract
MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and important pathways in regulating protein degradation and signal transduction, in which E3 ubiquitin ligases and deubiquitinases (DUBs) play a decisive role. MiRNA and ubiquitination are involved in the regulation of most biological processes, including autophagy. Furthermore, in recent years, the direct interaction between miRNA and E3 ubiquitin ligases or deubiquitinases has attracted much attention, and the cross-talk between miRNA and ubiquitination system has been proved to play key regulatory roles in a variety of diseases. In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases.
Highlights
Regulation by Crosstalk betweenA living cell is a complex dynamic system which can respond and adapt to environmental changes and stress all of the time
Both ubiquitination and miRNAs are key regulators of protein and related signaling involved in most biological processes such as cell cycle differentiation and apoptosis, and autophagy is no exception given its central role in cellular stress and survival responses
Ubiquitin–proteasome systems are involved in almost all cell signaling regulation such as cell cycle, cell proliferation, apoptosis, and autophagy [163–165]
Summary
A living cell is a complex dynamic system which can respond and adapt to environmental changes and stress all of the time. Ubiquitin proteasome system (UPS) is one of the main pathways regulating protein degradation in eukaryotic cells and is a key regulatory mechanism in a variety of biological processes [1]. MiRNA can inhibit the expression of target genes at the translation level or directly lead to the degradation of mRNA through complementary binding with target mRNA [10–12]. Both ubiquitination and miRNAs are key regulators of protein and related signaling involved in most biological processes such as cell cycle differentiation and apoptosis, and autophagy is no exception given its central role in cellular stress and survival responses. There is crosstalk between ubiquitin ligases, deubiquitinases, and
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