Abstract
In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double‐membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their contents to recycle the cellular components. Autophagy has been implicated in a wide variety of physiological and pathological processes that are closely related to tumorigenesis. In recent years, an increasing number of studies have indicated that nonsteroidal anti‐inflammatory drugs, such as celecoxib, meloxicam, sulindac, aspirin, sildenafil, rofecoxib, and sodium salicylate, have diverse effects in cancer that are mediated by the autophagy pathway. These nonsteroidal anti‐inflammatory drugs can modulate tumor autophagy through the PI3K/Akt/mTOR, MAPK/ERK1/2, P53/DRAM, AMPK/mTOR, Bip/GRP78, CHOP/ GADD153, and HGF/MET signaling pathways and inhibit lysosome function, leading to p53‐dependent G1 cell‐cycle arrest. In this review, we summarize the research progress in autophagy induced by nonsteroidal anti‐inflammatory drugs and the molecular mechanisms of autophagy in cancer cells to provide a reference for the potential benefits of nonsteroidal anti‐inflammatory drugs in cancer chemotherapy.
Highlights
Over the past few decades, much of cancer research has been focused on the mechanisms of apoptosis
The antitumor effects of Nonsteroidal anti-inflammatory drugs (NSAIDs) are related to their autophagy-modulating effects: either activation or inhibition of autophagy
It is important to determine the fate of tumor cells treated with NSAIDs
Summary
Over the past few decades, much of cancer research has been focused on the mechanisms of apoptosis. Certain pathways of programmed cell death have been shown to be inhibited either in the presence of autophagic inhibitors or when the expression of the autophagy-specific genes (ATGs) that regulate autophagy is reduced [37, 38]. OSU-0 3012 is a derivative of celecoxib, a COX-2 inhibitor, with anticancer activity that has been shown to induce the death of various types of cancer cells [57].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
