Abstract
Autophagy Inhibition Enhances the Mitochondrial-Mediated Apoptosis Induced by Mangrove (Avicennia marina) Extract in Human Breast Cancer Cells
Highlights
Breast cancer remains to be one of the deadly diseases in the world and is a leading cause of death among woman globally
We evaluated the molecular mechanisms underlying the apoptotic effects of ethyl acetate extract from leaves and stems of A. marina (AM) against MCF-7 cancer cell line
Since autophagy involves the recycling of macromolecules and damaged organelles and serves as a survival mechanism for cancer cell, while the excessive autophagy leads to cell death [19], we aimed at studying the interplay of autophagy and apoptosis in AM extract treated cancer cells
Summary
Breast cancer remains to be one of the deadly diseases in the world and is a leading cause of death among woman globally. Some of the reported traditional medicinal uses of A. marina (AM) extract include the astringent and antifertility effects [2], and treatment of rheumatism, small pox and ulcers [3]. Toxicological studies of leaf extract of AM regarding haemotological, biochemical and pathological effects in rats [2] have reported only minor adverse effects, and validated the use of plant leaves as a herbal remedy and an animal feed in drought stricken areas. We evaluated the molecular mechanisms underlying the apoptotic effects of ethyl acetate extract from leaves and stems of AM (referred as AM extract) against MCF-7 (breast adenocarcinoma) cancer cell line. Since autophagy involves the recycling of macromolecules and damaged organelles and serves as a survival mechanism for cancer cell, while the excessive autophagy leads to cell death [19], we aimed at studying the interplay of autophagy and apoptosis in AM extract treated cancer cells
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