Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights.

Abstract

According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed thatH. pyloriinfection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused onH. pylori's role in GC development. According to our hypothesis, however,H. pyloriinfection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding howH. pyloripossess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients withH. pyloriinfection with targeting autophagy and eradicatingH. pyloriinfection.