Abstract

Autophagy is a lysosome-mediated degradation process that takes part in maintaining cell stability. In the early stage of gastrointestinal tumors, autophagy removes toxic injuries to protect against tumor progression, while in the progressive stage, autophagy also exhibits a cytotoxic effect. Autophagy and apoptosis act in both antagonistic and synergistic fashion. Manipulation of autophagy may be a new method to prevent or treat gastrointestinal tumors. Key words: Autophagy; Gastrointestinal neoplasms; Apoptosis

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